|
KMID : 0363620080290040133
|
|
Journal of Korean Oriental Medicine
2008 Volume.29 No. 4 p.133 ~ p.145
|
|
|
The Effects of Hirudo on Streptozotocin-induced Diabetic Nephropathic Rats
|
|
Seo Su-Hwan
Kim Yong-Sung
Han Yang-Hee
|
|
|
Abstract
|
|
|
Objectives: The aim of present study was to investigate recovery effects of Hirudo, which has been used clinically in diabetes therapy.
Methods: We established three groups: normal, control, Hirudo, and assigned 6 rats to each group. The normal group was not treated by any process and fed by normal saline. The control & Hirudo groups were administered streptozotocin (STZ) to induce diabetes. Hirudo extract was orally administered to the Hirudo group for 10 days. After 8 weeks, the rats were sacrificed and their body weight, 24hrs urinary protein excretion, glucose, albumin, BUN, creatinine, total-cholesterol, LDL-cholesterol, triglyceride in blood, and level of glycation end-product (AGE) and transforming growth factor (TGF-) in serum were measured. Morphological profiles and morphometric studies of the kidney cortex, renal transforming growth factor (TGF-) expression, and renal receptor for advanced glycation end-products (RAGE) expression were studied.
Results: The following results were obtained. The protein amount in urine per 24hrs of the Hirudo-treated group as compared to the control group was significantly reduced. The BUN and creatinine level in serum of the Hirudo-treated group as compared to the control group was significantly inhibited. The construction change in kidney of the Hirudo-treated group as compared to the control group was significantly inhibited. The factor of the Hirudo-treated group as compared to the control group was significantly inhibited, which induced the construction change in kidney.
Conclusions: The above results suggest that Hirudo partially improved the function of the kidney.
|
|
|
KEYWORD
|
|
|
Hirudo, streptozotocin, diabetic nephropathy
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|